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Forum - Wall Street Pit (Gilead Sciences - GILD)    Stock Due Diligence for All

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From: crainiac (Rep: 4158)Date: 01/23/2020 15:25
Forum: Wall Street Pit - Msg #2812646 - List GILD msgs Thread #674118558 (Rec: 0)
n summary, our work provides evidence that GS-5734 is highly active against CoVs and that there is a high genetic barrier to achieve resistance. Additionally, resistant virus suffers a loss of competitive fitness in vitro and attenuation in animals, suggesting these mutations will not favor disease emergence and are likely to be poorly maintained in nature, particularly during acute infections. Finally, the results identify potential novel determinants of polymerase function and nucleotide selectivity or fidelity that will guide future structure-function and biochemical studies of the polymerase and GS-5734 mechanism. Together, these results argue strongly for the continued clinical development of GS-5734 to treat MERS-CoV and demonstrate its potential utility in the broad-spectrum treatment of CoV infections.

https://mbio.asm.org/content/9/2/e00221-18

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